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Figure 1 | Virology Journal

Figure 1

From: The modulation of apoptosis by oncogenic viruses

Figure 1

Apoptotic signaling pathways. The extrinsic pathway is regulated by membrane receptors. The interaction with their ligands Fas, Trail and TNF, favors their trimerization, inducing the recruitment of FADD through the interaction with their death domains (DDs). The interaction of FADD with procaspase 8 forms a complex called DISC, which favors its oligomerization and auto-cleavage. Active caspase 8 initiates the cascade of effector caspases 3, 6 and 7. In the intrinsic pathway, Bax and Puma are translocated from the cytosol to the mitochondrial membrane as a result of DNA damage, thus provoking the release of cytochrome c. Cytochrome c participates in the formation of the apoptosome, which is involved in DNA degradation. AIF contribute to DNA and nuclear fragmentation.

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