Figure 2

Evaluation of potential cross-reactivity between human GII.4 NoV IgG antibodies and canine NoV VLPs. Two sera with low (LAT) and high (HAT) CaNoV antibody titer were pre-incubated with a 2-fold serial dilution of CaNoV VLPs (5, 2.5, 1.25, 0.625, 0.3125 μg/ml) and tested for antibodies against CaNoV VLPs (A) and human GII.4 NoV VLPs (B). Values are the corrected optical densities (OD) at 450 nm [OD₄₅₀ (VLP coated) - OD₄₅₀ (non-coated)] for each serum sample. Dotted lines represent the logistic regression of HAT values, solid lines represent the logistic regression of LAT values.