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Table 2 IFN-α improve the chemosensitivity of Huh7-HBx xenograft mice model to ADM treatment

From: Interferon-α sensitizes HBx-expressing hepatocarcinoma cells to chemotherapeutic drugs through inhibition of HBx-mediated NF-κB activation

Treatment (n = 5)

Tumor weight (g)

Growth inhibition (%)

P, t-Test

Vehicle

2.102 ± 0.165

-

-, -

ADM

1.31 ± 0.159

37.69

p<0.01, -

IFN-α

1.75 ± 0.135

16.73

p<0.05, -

ADM + IFN-α

0.725 ± 0.098

65.49

p<0.01, *p<0.01

ADM + IMD

0.622 ± 0.095

70.41

p<0.01, *p<0.01

  1. Student’s t test was used to assess the significance of tumor growth inhibition between each group. Left “p”: each group compared with vehicle (saline treated Huh7-HBx bearing group). Right “*p”: ADM + IFN-α or ADM + IMD treated group compared with ADM treated group.
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Virology Journal

ISSN: 1743-422X