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Table 1 HBx reduces the chemosensitivity of Huh7 in xenograft mice model

From: Interferon-α sensitizes HBx-expressing hepatocarcinoma cells to chemotherapeutic drugs through inhibition of HBx-mediated NF-κB activation

Tumor

Treatment (n = 5)

Dosage (mg/kg × d)

Tumor weight (g)

Growth inhibition (%)

P, t-Test

Huh7

Vehicle

0

2.089 ± 0.229

-

-

Huh7-3.1

Vehicle

0

2.11 ± 0.259

-

p>0.05

Huh7-HBx

Vehicle

0

2.068 ± 0.195

-

p>0.05

Huh7

5-FU

25

0.528 ± 0.19

74.72

-

Huh7-3.1

5-FU

25

0.608 ± 0.253

71.18

p>0.05

Huh7-HBx

5-FU

25

1.25 ± 0.307

39.56

p<0.01

Huh7

ADM

2

0.661 ± 0.218

68.36

-

Huh7-3.1

ADM

2

0.652 ± 0.162

69.1

p>0.05

Huh7-HBx

ADM

2

1.194 ± 0.211

42.26

p<0.01

  1. Student’s t test was used to assess the significance of tumor growth inhibition of each group compared with vehicle (normal saline -treated group).