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Figure 4 | Virology Journal

Figure 4

From: Interferon-α sensitizes HBx-expressing hepatocarcinoma cells to chemotherapeutic drugs through inhibition of HBx-mediated NF-κB activation

Figure 4

Interferon-α diminishes Huh7-HBx cells resistance to ADM. A) Apoptotic index quantitated by FACS. Compared with Huh7-HBx cells treated with either IFN-α or ADM, the cells treated with both IFN-α and ADM clearly showed an increase in annexin+/PI- & annexin+PI+ cell population. Data are showed as mean ± SD, and statistically analyzed with Student’s t test assay. * P < 0.05, ** P < 0.01, each cells v.s. controle (non-treated Huh7-HBx cells). B) The transcript level of the anti-apoptosis genes in Huh7-HBx cells (control) and IFN-α or IMD-0354 pretreated Huh7-HBx cells were detected by real-time RT-PCR analysis, with β-actin as internal control. Logarithmic scale expression values were normalized to Huh7-HBx (ref =1, n = 3).

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