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Figure 1 | Virology Journal

Figure 1

From: Interferon-α sensitizes HBx-expressing hepatocarcinoma cells to chemotherapeutic drugs through inhibition of HBx-mediated NF-κB activation

Figure 1

Increase in drugs resistance induced by HBx. A) The IC50 value of ADM and Amn against Huh7, Huh7-3.1, and Huh7-HBx cells respectively. Huh7-HBx cells represent a higher resistance of 2.317 and 1.828 times, respectively, than Huh7-3.1 cells against these two chemotherapeutic drugs. B) After treatment with ADM for 24 h, the Annexin V/PI assay was used for the analysis of cell apoptosis. A significantly less degree of apoptosis was found in Huh7-HBx cell than in Huh7-3.1 cell (P < 0.05). C) Cell cycle analysis of Huh7, Huh7-3.1 and Huh7-HBx cells after 24 h of treatment with ADM, as determined by flow cytometry for DNA content.

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Virology Journal

ISSN: 1743-422X