Phylogenetic tree depicting the HCV NS5b ( A ) or the core-E1 junction ( B ) genomic region of the analyzed isolates. HCV isolates characterized in the study are highlighted with symbols (circle, subtype 1b; square, subtype 1a; diamonds, subtype 2b; triangles, subtype 3a). Only bootstrap support values above 80% are shown, which differentiate major HCV genotypes and subtypes. The tree was rooted with a subtype 7a sequence, a variant not found in Brazil. Bars below the trees represents a genetic distance of 5% at the nucleotide level.