IDO is Not Required for MAIDS at Different Timepoints or Doses of LP-BM5. LP-BM5-induced disease kinetics were assessed in B6 and B6.IDO−/− mice. (A) B6 and B6.IDO−/− mice were infected in parallel, with 5x104 pfu of LP-BM5 virus. MAIDS parameters were assessed at 3, 5, and 8 wpi and disease index was determined. (B) B6 and B6.IDO−/− mice were infected with LP-BM5 at a dose of 5x103 or 1x104 pfu. Disease parameters were assessed at 8 wpi and disease index was calculated. Histograms represent the mean, (n = 3), with indicated standard deviations. The patterns of the presented results are representative of two additional experiments, which provided a similar pattern of results. *p < 0.05, in comparison to 5x103 pfu, as determined using one-way ANOVA.