Detection of specific HPV subtypes responsible for the pathogenesis of condylomata acuminata

Table 4 Identification of candidate HPV types causing wart lesion development

Sample #	Infection candidates (refer Table2)	Potential cause of lesion (RNA analyses)
1	11, 81	6^b
2	6^a, 45, 52	6^a
3	6, 18, 45, 52	11^d
4	6^a, 45, 81	6^a, 11^d
5	6^a, 53	6^a, 52^c
6	6^a	6^a
7	6^a, 42, 59	6^a
8	6^a	6^a
9	6^a	6^a, 11^d
10	6^a	6^a
11	55	6^b, 11^d
12	11^a, 16^a, 81	11^a, 16^a
17**	-	11^b

Identification of candidate HPV types causing warts by HPV E6 RNA as arbiter of type involvement compared to laser capture & microdissection (LCM) with DNA typing.*Absence of HPV type in swab, lower and upper layers cannot rule out possibility of contamination (since wart tissue contains both contaminants and non-contaminants). **Absence of LCM cannot confirm any HPV type as truly non-contaminant. CP^$ abbreviated for CP6108 and is now known as HPV 89. HPV types correctly identified as infection candidates are highlighted by superscript (a); HPV types identified as potentially causing lesion development in the ‘undetermined’ category are highlighted by superscript (b); HPV types incorrectly identified as surface contaminants have been highlighted by superscript (c); HPV types potentially causing wart lesion development but not detected using Linear Array are highlighted by superscript (d).

ISSN: 1743-422X