Skip to main content
Figure 9 | Virology Journal

Figure 9

From: A novel platform for virus-like particle-display of flaviviral envelope domain III: induction of Dengue and West Nile virus neutralizing antibodies

Figure 9

Induction of flavivirus neutralization antibodies by VLP-displayed DIII antigen. The occurrence of anti-DENV1 or anti-WNVKun neutralizing antibodies in sera of mice immunized with VLPs displaying the corresponding DIII at their surface was determined using plaque reduction neutralization test (PRNT). (A), Sera from mice immunized with VLP-DENV1 were diluted to 1:10 and tested against live DENV1 virions. (B), Sera from mice immunized with VLP-WNVKun (1:10 dilution) were tested against live WNVKun virions. Neutralization activity of sera was expressed as the percentage of virus neutralization, based on plaque determinations (average of three determinations, m ± SD).

Back to article page

Virology Journal

ISSN: 1743-422X