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Figure 4 | Virology Journal

Figure 4

From: A monoclonal antibody against lymphocyte function-associated antigen-1 decreases HIV-1 replication by inducing the secretion of an antiviral soluble factor

Figure 4

LFA-1 MAb induces the production of an anti-viral soluble factor. PBMC from six HIV negative (open symbols) and eight HIV-1 positive subjects (closed symbols) were incubated for 24 hours in the presence of increasing concentrations of LFA-1 MAb or PBS alone (x-axis). Supernatant was harvested from these cultures then mixed with fresh CD8-depleted PBMC and subsequently infected with 10 TCID50 of HIV-SF162. The degree of viral replication was measured on day 7 using a p24 ELISA. There was a significant decrease in the mean concentration of p24 (indicated by the horizontal line) in cultures containing LFA-1 MAb (p = 0.0006, one way ANOVA).

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Virology Journal

ISSN: 1743-422X