Skip to main content
Figure 5 | Virology Journal

Figure 5

From: Consistent high concentration of the viral microRNA BART17 in plasma samples from nasopharyngeal carcinoma patients - evidence of non-exosomal transport

Figure 5

Evolution of miR-BART17 concentrations in plasma samples from an NPC patient with rapid disease progression. Several plasma samples were sequentially collected from the NPC patient n°5. Two of them were obtained prior to any treatment. The third one was obtained 5 weeks after completion of chemoradiotherapy in a context of very rapid, quasi-immediate, metastatic relapse. This tumor was initally localized (T2N2M0) but it was highly hypermetabolic as shown on the sagittal image of 18Fluoro Deoxyglucose Positron Emission Tomography (FDG-PET) combined to the computed tomography (CT) scan (SUVmax = 30.9). Data from miR-BART17 PCR-amplification were normalized using data from concomitant cel-miR-39 amplification. Relative amounts of miR-BART17 were calculated according to the 2-ΔCt method. Error bars refer to standard deviations. In the final sample collected in the context of the metastatic relapse, the concentration of plasma miR-BART17 was more than 100 times higher than in the initial sample.

Back to article page