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Table 1 Antiviral activity of Stachyflin on influenza A virus

From: Antiviral activity of stachyflin on influenza A viruses of different hemagglutinin subtypes

Subtype

Virus strain

EC50(μM)a

 H1

A/WSN/1933 (H1N1)

0.05

 

A/swine/Hokkaido/2/1981 (H1N1)

0.24

 

A/Puerto Rico/8/1934 (H1N1)

0.49

 

A/Narita/1/2009 (H1N1) pdm

1.95

 H2

A/Singapore/1/1957 (H2N2)

0.16

 H3

A/duck/Hokkaido/5/1977 (H3N2)

>6.50

 H4

A/duck/Czech/1956 (H4N6)

>6.50

 H5

A/Hong Kong/483/1997 (H5N1)

1.95

 

A/whooper swan/Hokkaido/1/2008 (H5N1)

2.05

 

A/duck/Hokkaido/Vac-1/2004 (H5N1)

0.86

 

A/chicken/Ibaraki/1/2005 (H5N2)

0.17

 

A/chicken/Taiwan/A703-1/2008 (H5N2)

>6.50

 

A/whooper swan/Mongolia/3/2005 (H5N1)

4.70

 

A/peregrine falcon/Hong Kong/810/2009 (H5N1)

>6.50

 H6

A/turkey/Massachusetts/3740/1967 (H6N2)

0.53

 

A/duck/Hokkaido/31/2010 (H6N2)

0.65

 

A/gull/Tottori/105/1980 (H6N3)

0.65

 

A/duck/Taiwan/4801/1990 (H6N5)

0.44

 

A/duck/Vietnam/OIE-2574/2011 (H6N6)

>6.50

 H7

A/turkey/Italy/4580/1999 (H7N1)

>6.50

 

A/chicken/Netherland/2586/2003 (H7N7)

>6.50

 H8

A/turkey/Ontario/6118/1968 (H8N4)

>6.50

 H9

A/chicken/Yokohama/aq-55/2001 (H9N2)

>6.50

 

A/Hong Kong/1073/1999 (H9N2)

>6.50

 H10

A/chicken/Germany/N/1949 (H10N7)

>6.50

 H11

A/duck/England/1/1956 (H11N6)

>6.50

 H12

A/duck/Alberta/60/1976 (H12N5)

>6.50

 H13

A/duck/Siberia/272PF/1998 (H13N6)

>6.50

 H14

A/mallard/Astrakhan/263/1982 (H14N5)

>6.50

 H15

A/duck/Australia/341/1983 (H15N8)

>6.50

 H16

A/black-headed gull/Sweden/5PF/1999 (H16N3)

>6.50

  1. a The compound concentration producing 50% inhibition of virus replication, as estimated by microscopic scoring of the CPE. The data shown are the means of 3 experiments.