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Table 5 Conservation and variability analysis of B-cell and T-cell epitopes in comparison with HCV E1 proteins of other regions

From: Structural analysis and epitope prediction of HCV E1 protein isolated in Pakistan: an in-silico approach

Peptide India Russia Japan USA China Nepal Yemen France Canada Somalia
VGQAFTFRPRRH VS QL FTFS PRRH VS QL FTFS PRRH IS QL FTFS PRRH VGQL FTFS PRH H AA QL FIIS PXHH VGQAFTFS PRRH VGQVI TFK PRRH VGQM FTY RPRQ H VGQAFTFRPRRH VGQAFR FRQ RQ H
TPVTPTVAVRYV VAL TPTL AA RNA VAL TPTL AA RNA VAL TPTL AA RNS VA VA PTVAT RDG I PVS PNI AVQQP TPVS PTVAVKHL K PVTPTVAVA YG VQI TPTLSAPSF TPVTPTVAVRYV TPVTPTVAVRAP
TPGCIPCVQDGN TPGCV PCVRE GN TPGCV PCVQED N TPGCV PCVRE GN S PGCV PCVRE GN V PGCV PCEKV GN L PGCV PCVATA N L PGCV PCVKT GN TPGCV PCVKE GN TPGCIPCVQDGN S PGCV PCVKS GN
TNDCPNSSIVYE TNDCS NSSIVYE TNDCS NSSIVYE TNDCS NSSIVYE TNDCPNSSIVYE TNDCS ND SITWQ TNDCS NQ SIVYE TNDCPNSSV VYE TNDCPNSSIVYE TNDCPNSSIVYE TNDCPNSSIVYE
ATTASVRSH VP TTTIRR H VP TTAI RR H VP TTTI RR H LP TTQL RR H AL TRGL RT H ATTASI RSH APLE SF RR H AX TAPL RR A ATTASVRSH VI TASI RSH
MNWTPAVGM MNWS PTAAL MNWS PTTAL MNWS PTAAL MNWS PTTAL MNWS PTAT M MNWS PAIGL MNWS PTTTL MNWS PTTAL N/A Q NWS PT VSL
VGMVVAQVLRL AAL VVS QL LRI TAL VVS QL LRI AAL VAS QLF RI TAL VVAQLL RV AT MIL AYAM RI I GLA VSHLM RL TTLLL AQIM RI TALLM AQL LRI N/A VSLI VAQVLRL
LGGAHWGML VA GAHWGI L VA GAHWGV L VA GAHWGV L IA GAHWGV L IS GAHWGVM IA GAHWGVM VA GG HWGV L VA GG HWGV L N/A LV GS HWGV L
SHVDLLVGA R HVDLLVGA R HVDLLVGA R HVDLLVGA R HI DLLVGS T HI DMV VMS SHVDM LVGA R HVDLM VGA RA VDY LA GG SHVDLLVGA SHVDLM VGS
LTNDCPNSS V TNDCS NSS V TNDCS NSS V TNDCS NSS V TNDCPNSS V TNDCS ND S LTNDCS NQ S I TNDCPNSS V TNDCPNSS LTNDCPNSS V TNDCPNSS
WTPVTPTVA WVAL TPTL A WVAL TPTL A WVAL TPTL A WVA VA PTVA WI PVS PNI A WTPVS PTVA WK PVTPTVA WVQI TPTLS WTPVTPTVA WTPVTPTVA
VRYVGATTASV A RNASVP TTTI A RNASVP TTAI A RNSNVP TTTI T RDGKLP TTQL VQQP GAL TRGL VKHL GATTASI VA YGS APLE SF APSF GAX TAPL VRYVGATTASV VRAP GVI TASI
YVGATTASV NASVP TTTI NASVP TTAI NSNVP TTTI DGKLP TTQL QP GAL TRGL HL GATTASI YGS APLE SF SF GAX TAPL YVGATTASV AP GVI TASI
VRYVGATTA A RNASVP TT A RNASVP TT A RNSNVP TT T RDGKLP TT VQQP GAL TR VKHL GATTA VA YGS APLE APSF GAX TA VRYVGATTA VRAP GVI TA
  1. Variable residues in epitopes are shown in bold.