The tree shrew provides a useful alternative model for the study of influenza H1N1 virus

Table 1 Virus, clinical signs, virus replication, and seroconversion of tree shrews

Virus	Body weight (g)^a	Body temperature (°C)^b	Nasopharyngeal secretion	Peak mean nasal wash titer±SD (day)^d	Number positive/total (average logTCID₅₀/mL)^e			Seroconversion(HI titer)^f
					Nasal mucosa	Tracheal	Lung
A/PR8/34	99.77±0.42	39.78±0.44	Positive (3/3)^c	2.94±0.92 (2)	(3/3) (1.89)	(0/3)	(0/3)	(3/3) 80,80,320
GZ/02/09	98.92±0.63	40.26±0.55	Positive (3/3)	3.00±0.33 (2)	(3/3) (1.90)	(0/3)	(0/3)	(3/3) 80,160,640
S-OIV/GZ/07/09	100.24±0.49	40.57±0.59	Positive (3/3)	4.24±0.25 (1)	(3/3) (2.17)	(0/3)	(0/3)	(3/3) 80,160,640
Control	99.46±0.36	38.20±0.47	No	0	(0/3)	(0/3)	(0/3)	(0/3) 0,0,0

^a Bodyweight on day o.
^b Average body temperature on day 2 p.i.
^c Number of inoculated tree shrews/total number.
^d Peak nasal wash titers are expressed as the mean±SD log10 TCID₅₀/mL.
^e Virus titers in different tissues was detected on day 2 p.i.
^f Serum was collected on day 14 p.i., and homologous strains were used with chicken RBCs in HI assay.

ISSN: 1743-422X