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Figure 2 | Virology Journal

Figure 2

From: Inhibition of p38MAPK and CD137 signaling reduce dengue virus-induced TNF-α secretion and apoptosis

Figure 2

Decreased apoptosis in p38 MAPK knockdown HepG2 cells expressing DENV C. HepG2 cells expressing DENV C or control plasmid were transfected either with siRNA directed against p38 MAPK or with control siRNA and then treated with 0.5 μg/ml anti-Fas mAb and 1 ug/ml cycloheximide for 24 h. Cells were collected and analyzed for (A) p38 MAPK, DENV C and actin (B) Bar graph represents apoptosis experiments. All data were obtained from three independent experiments and reported as the mean ± SEM. Statistical differences between the groups were tested with an unpaired t-test using StatView version 5.0 and P value less than 0.05 was considered significant. (C) Apoptosis by flow cytometry.

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