Figure 4

Protective efficacy against a heterologous influenza viruses challenge. Immunized mice were intranasally challenged with 2LD₅₀ of an A/aquatic bird/Korea/maW81/05 (maW81/H5N2) influenza virus. Changes in body weight and survival were recorded daily post-challenge. (A) The average percent of initial weight is expressed as a percentage of the weight of the examined day relative to weight prior to challenge. (B) Survival was monitored for 14 days post-challenge. And mice were challenged with a lethal dose of A/Philippines/2/82 (Phil82/H3N2) influenza virus. (C) Body weight changes and (D) survival are shown.