Figure 4

Window-averaged scores for sequence identity among the T1L, T2J, and T3D μ2 proteins. Identity scores averaged over running windows of 21 amino acids and centered at consecutive amino acid positions are shown. The global identity score for the three sequences is indicated by the dashed line. Two extended areas of greater-than-average sequence variation are marked with lines below the plot. Two extended areas of greater-than-average sequence conservation are marked with lines above the plot. Eight regions of ≥ 15 consecutive residues of identity among all twelve μ2 sequences from Fig. 2, as discussed in the text, are numbered above the plot. The Ser/Pro208 determinant of microtubule binding is marked with a filled diamond. The two putative NTP-binding motifs are marked with filled circles.