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Figure 2 | Virology Journal

Figure 2

From: Comparisons of the M1 genome segments and encoded μ2 proteins of different reovirus isolates

Figure 2

Alignment of the deduced μ2 amino acid sequences of T1L, T2J, T3D, and various field isolates. The single-letter amino acid code is used, and only the T1L μ2 sequence from the Brown laboratory is shown in its entirety. For other isolates, only those amino acids that differ from this T1L sequence are shown. Clones arranged in same order as in Fig. 1; the second T1L μ2 sequence is from the Nibert and Coombs laboratories, the first T3D μ2 sequence is from the Joklik and Cashdollar laboratories, and the second T3D μ2 sequence is from the Nibert and Coombs laboratories. Amino acid positions are numbered above the sequences. Some symbols represent various nonconservative changes among the isolates: *, change involving a charged residue; § change involving an aromatic residue; †, change involving a proline residue; ‡, change involving a cysteine residue. Residue 208, which has been previously shown to affect microtubule association by μ2, is indicated by a filled diamond. Residues 410–420 and 446–449, which have been previously identified as NTP-binding motifs are indicated by filled circles. Consecutive runs of wholly conserved residues ≥ 15 amino acids in length are indicated by the lines numbered 1 to 8.

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