Skip to main content

Advertisement

Table 3 Induction Ratio (HSV+/Mock) of Transcripts for Chemokine Receptors, Chemokines and Cytokines in Cornea and Trigeminal Ganglia (TG)

From: Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection

  Corneaa TGb
Gene 3d 10d 30d 3d 10d 30d
CCR1 11 (9.2–12) 18 (13–23) 20 (10–26) 5 (2.2–7.1) 15 (9.0–19) 4 (1.7–7.0)
CCR2 14 (9.2–19) 22 (11–32) 14 (8.1–24) 3 (1.5–4.2) 15 (11–19) 3 (1.3–4.4)
CCR3 2 (1.0–5.0) 3 (2.0–5.0) 3 (2.5–3.3) 2 (0.5–5.0) 8 (2.2–20) 3 (1.8–4.7)
CCR5 12 (12.3–12.5) 11 (8.0–14) 20 (8.9–36) 9 (4.8–11) 57 (22–110) 9 (7.0–10)
CCR6 3 (2.4–3.0) 2 (1.0–2.5) 5 (1.5–8.5) 3 (0.3–11) 3 (1.0–5.0) 14 (1.0–40)
CCR7 24 (8.0–40) 5 (3.0–6.5) 17 (13–21) 13 (9.0–17) 19 (17–20) 7 (2.0–11)
CXCR3 10 (5.0–18) 15 (8.0–23) 5 (2.8–6.5) 2 (1.0–4.0) 104 (54–160) 36 (14–59)
CXCR4 11 (4.8–14) 3 (1.7–4.0) 45 (33–74) 0.6 (0.4–0.9) 4 (2.9–6.2) 3 (2.3–3.7)
MIP-1α 69 (33–106) 394 (263–1700) 34 (16–53) 232 (80–471) 126 (80–168) 25 (13–45)
MIP-1β 53 (39–67) 285 (261–310) 16 (11–21) 282 (10–595) 230 (202–245) 31 (24–37)
RANTES 55 (36–73) 43 (38–48) 16 (12–18) 64 (61–66) 304 (302–306) 31 (12–50)
MCP-1 54 (52–55) 64 (55–74) 12 (7.5–20) 153 (113–194) 22 (16–27) 3 (1.6–4.2)
Eotaxin-1 3 (1.9–3.5) 1 (0.6–1.3) 3 (1.0–5.4) 5 (3.3–9.1) 2 (1.2–2.8) 1.5 (0.7–2.3)
IFNγ Inf.c Inf. Inf. Inf. Inf. Inf.
TNF-α 3 (2.9–3.0) 3 (2.6–3.8) 7 (3.9–12) Inf. Inf. Inf.
  1. a Induction ratios were calculated as relative expression in HSV-infected/relative expression in mock-infected cornea. Each value is the average of induction ratios (2 or 3 separate measurements per cDNA sample) from two independent experiments. Ranges of individual ratios are in parentheses.
  2. b Induction ratios were calculated for HSV- vs. mock-infected TG as in footnote a. Each value is the average of induction ratios (2 or 3 separate measurements per cDNA sample) from three independent experiments, with ranges in parentheses.
  3. c Inf., infinite due to relative expression = 0 in all or most mock-infected samples.