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Table 2 Clinical trials and an approved therapy based on AS-ON technologies [31-33].

From: Biochemical prevention and treatment of viral infections – A new paradigm in medicine for infectious diseases

Product Company Target Disease Chemistry Status
Vitravene (Fomivirsen) ISIS Pharmaceuticals CMV IE2 CMV retinitis PS DNA Approved in 1998
Affinitac (ISIS 3521) ISIS PKC-α Cancer PS DNA Phase III
Genasense Genta Bcl2 Cancer PS DNA Phase III
Alicaforsen (ISIS 2302) ISIS ICAM-1 Psoriasis, Crohn's disease, Ulcerative colitis PS DNA Phase II/III
ISIS 14803 ISIS Antiviral Hepatitis C PS DNA Phase II
ISIS 2503 ISIS H-ras Cancer PS DNA Phase II
MG98 Methylgene DNA methyl transferase Solid tumors PS DNA Phase II
EPI-2010 EpiGenesis Pharmaceuticals Adenosine A1 receptor Asthma PS DNA Phase II
GTI 2040 Lorus Therapeutics Ribonucleotide reductase (R2) Cancer PS DNA Phase II
ISIS 104838 ISIS TNFα Rheumatoid Arthritis, Psoriasis 2nd generation Phase II
Avi4126 AVI BioPharma c-myc Restenosis, cancer, Polycystic kidney disease 3rd generation Phase I/II
Gem231 Hybridon PKA RIα Solid tumors 2nd generation Phase I/II
Gem92 Hybridon HIV gag AIDS 2nd generation Phase I
GTI 2051 Lorus Therapeutics Ribonucleotide reductase (R1) Cancer PS DNA Phase I
Avi4557 AVI BioPharma CYP3A4 Metabolic redirection of approved drugs 3rd generation Phase I