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Figure 3 | Virology Journal

Figure 3

From: Prevention of genital herpes in a guinea pig model using a glycoprotein D-specific single chain antibody as a microbicide

Figure 3

Single plain view of a 3-D model of DL11 scFv, showing its predicted structure. Panel A: Strand view, colored by group, demonstrates relative orientation of the kappa (top) and gamma (bottom) chains, which shows the positions of residues to which the (Gly4Ser)3 hinge is attached. Panel B: Wireframe image illustrating hinge attachment sites on one side of the molecule (linked by dashed line) and clustering on the opposite side (inside the circle) of the complementary determining regions (CDRs) predicted by the Kabat antibody database. The clustering of CDRs suggests correct conformation of the molecule with formation of an antigen binding site.

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